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Title 

Two new lignans from the roots of Pulsatilla koreana

Authors 

T D CuongT M HungJ C KimJ I HuhS J KwackT S KangJung Hee KimH S JangJ S ChoiHyeong Kyu LeeK BaeM S Min

Publisher 

Georg Thieme Verlag

Issue Date 

2011

Citation 

Planta Medica, vol. 77, no. 1, pp. 66-69

Keywords 

anticomplement activitylignanPulsatilla koreanaRanunculaceae

Abstract 

Two new lignans, (2R,3R)-2β-(4-hydroxy-3α-methoxybenzyl)-3-(4- hydroxy-3'-methoxybenzyl) -γ- butyrolactone 2-O-(β-D-glucopyranoside) (1) and (1S,2R,3S)-dimethyl-1,2,3,4-tetrahydro-3,6,7-trihydroxy-1-(3,4- dihydroxyphenyl)naphthalene-2,3-dicarboxylate (2) together with nine known compounds (3-11) were isolated from the ethyl acetate fraction of the roots of Pulsatilla koreana. Their chemical structures were established based on physicochemical and spectroscopic data analyses. All isolates were investigated for their inhibition effects against the classical pathway of the complement system. Among them, compound 6 showed significant inhibitory activity with an IC50 value of 75.9 μM, compounds 8 and 9 had moderate effects with IC50 values of 182.2 and 166.5 μM, respectively.

ISSN 

0032-0943

Link 

http://dx.doi.org/10.1055/s-0030-1250122

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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