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Title 

Clec14a is specifically expressed in endothelial cells and mediates cell to cell adhesion

Authors 

S S RhoH J ChoiJ K MinH W LeeH ParkY M KimY G Kwon

Publisher 

Elsevier

Issue Date 

2011

Citation 

Biochemical and Biophysical Research Communications, vol. 404, no. 1, pp. 103-108

Keywords 

AngiogenesiC-type lectin like domainCell-cell adhesionClec14aEndothelial cell

Abstract 

Clec14a is a member of the thrombomodulin (TM) family, but its function has not yet been determined. Here, we report that Clec14a is a plasma membrane protein of endothelial cells (ECs) expressed specifically in the vasculature of mice. Deletion mutant analysis revealed that Clec14a mediates cell-cell adhesion through its C-type lectin-like domain. Knockdown of Clec14a in ECs suppressed cell migratory activity and filopodial protrusion, and delayed formation of tube-like structures. These findings demonstrate that Clec14a is a novel EC-specific protein that appears to play a role in cell-cell adhesion and angiogenesis.

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1016/j.bbrc.2010.11.075

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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