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Title 

Oxygenated hexylitaconates from a marine sponge-derived fungus Penicillium sp.

Authors 

J L LiP ZhangY M LeeJ HongE S YooKyung Sook BaeJ H Jung

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2011

Citation 

Chemical & Pharmaceutical Bulletin, vol. 59, no. 1, pp. 120-123

Keywords 

Anti-inflammatoryCytotoxicityDicarboxylic acidHexylitaconatePenicillium sp.Sponge-derived fungus

Abstract 

In the course of our search for bioactive metabolites from marine organisms, new hexylitaconic acid derivatives (1-4), along with (3S)-hexylitaconic acid (5), were isolated from a sponge-derived fungus Penicillium sp. Based on the NMR and MS data, the structures of compounds 1-4 were defined as α,β-dicarboxylic acid derivatives, such as hexylitaconic acid and tensyuic acids which were previously reported as metabolite of Aspergillus niger, Penicillium striatisporum, or Apiospora montagnei. The isolated compounds were evaluated for cytotoxicity against a panel of five human solid tumor cell lines, and for anti-inflammatory activity gauged by their inhibitory effects on the production of major pro-inflammatory mediators (nitric oxide (NO), interleukin (IL)-6, tumor necrosis factor (TNF)-α, and IL-1β) in murine macrophage cells. Compounds 1 and 4 showed weak inhibition of IL-1β production at the concentration of 200 μM.

ISSN 

0009-2363

Link 

http://dx.doi.org/10.1248/cpb.59.120

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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