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Title 

Biological evaluation of KRIBB3 analogs as a microtubule polymerization inhibitor

Authors 

Sangku LeeJ N KimHyeong Kyu LeeKab Seog YoonK D ShinByoung-Mog KwonDong Cho Han

Publisher 

Elsevier

Issue Date 

2011

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 21, no. 3, pp. 977-979

Keywords 

Anti-mitoticCancerInhibitionIsoxazoleMicrotubule

Abstract 

A series of KRIBB3 analogs were synthesized by modifying substituents at aryl moieties of KRIBB3 for examining structure-activity relationships, and their inhibitory activities on microtubule polymerization were evaluated. The presence of free phenolic hydrogens in aryl moieties of KRIBB3 analogs plays an important role in inhibition of microtubule polymerization.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2010.12.044

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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