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Title 

Manassantin A and B from Saururus chinensis inhibit interleukin-6-induced signal transducer and activator of transcription 3 activation in Hep3B cells

Authors 

Jong Sun ChangSeung Woong LeeM S KimBo Ra YoonMi-hye ParkS G LeeSu-Jin ParkWoo Song LeeMun Chual Rho

Publisher 

Japanese Pharmacological Society

Issue Date 

2011

Citation 

Journal of Pharmacological Sciences, vol. 115, no. 1, pp. 84-88

Keywords 

Interleukin-6Manassantin A and BSignal transducer and activator of transcription 3 (Stat3)

Abstract 

Inhibition of interleukin-6 (IL-6) has been postulated to be an effective therapy in the pathogenesis of several inflammatory diseases. The current study was performed to examine potential effects of manassantin A and B isolated from Saururus chinensis on the IL-6-induced response to human hepatoma cells. We found that manassantin A and B inhibit signal transducer and activator of transcription 3 (Stat3) activity stimulated by IL-6. We also found that both compounds decreased IL-6-induced Stat3 phosphorylation and nuclear translocation. Both compounds blocked suppressor of cytokine signaling 3 (SOCS-3)-mRNA expression induced by IL-6. In addition, we found that Stat3 inhibitory effects of these compounds could be related to protein tyrosine phosphatase. These findings suggest that manassantin A and B could be useful remedies for treatment of inflammatory diseases by inhibiting IL-6 action.

ISSN 

1347-8613

Link 

http://dx.doi.org/10.1254/jphs.10239SC

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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