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Title 

Neuronal gene for subcutaneous fat thickness in human and pig are identified by local genomic sequencing and combined SNP association study

Authors 

K T LeeM J ByunK S KangE W ParkS H LeeS ChoH Y KimK W KimT LeeJ E ParkW ParkD ShinHong-Seog ParkJ T JeonB H ChoiG W JangSang-Haeng ChoiD W KimD LimH S ParkM R ParkJ OttL B SchookT H KimH Kim

Publisher 

Public Library of Science

Issue Date 

2011

Citation 

Plos One, vol. 6, no. 2, pp. e16356-e16356

Abstract 

Obesity represents a major global public health problem that increases the risk for cardiovascular or metabolic disease. The pigs represent an exceptional biomedical model related to energy metabolism and obesity in humans. To pinpoint causal genetic factors for a common form of obesity, we conducted local genomic de novo sequencing, 18.2 Mb, of a porcine QTL region affecting fatness traits, and carried out SNP association studies for backfat thickness and intramuscular fat content in pigs. In order to relate the association studies in pigs to human obesity, we performed a targeted genome wide association study for subcutaneous fat thickness in a cohort population of 8,842 Korean individuals. These combined association studies in human and pig revealed a significant SNP located in a gene family with sequence similarity 73, member A (FAM73A) associated with subscapular skin-fold thickness in humans (rs4121165, GC-corrected p-value = 0.0000175) and with backfat thickness in pigs (ASGA0029495, p-value = 0.000031). Our combined association studies also suggest that eight neuronal genes are responsible for subcutaneous fat thickness: NEGR1, SLC44A5, PDE4B, LPHN2, ELTD1, ST6GALNAC3, ST6GALNAC5, and TTLL7. These results provide strong support for a major involvement of the CNS in the genetic predisposition to a common form of obesity.

ISSN 

1932-6203

Link 

http://dx.doi.org/10.1371/journal.pone.0016356

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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