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Title 

An increase in mouse tumor growth by an in vivo immunomodulating effect of titanium dioxide nanoparticles

Authors 

E Y MoonG H YiJong Soon KangJ S LimHwan Mook KimS Pyo

Publisher 

Informa Healthcare

Issue Date 

2011

Citation 

Journal of Immunotoxicology, vol. 8, no. 1, pp. 56-67

Keywords 

B-lymphocyteB16F10 melanomamacrophagenanoparticlesNK cellsplenocyteT-lymphocyteTiO 2

Abstract 

Here, we investigated whether titanium dioxide (TiO(2)) nanoparticles affect in vivo tumor growth through the modulation of mononuclear leukocytes. In vitro lymphocyte proliferation by lipopolysaccharide (LPS) or concanavalin A (ConA) was reduced by < 25?nm TiO(2) with a dose-dependent manner. Similarly, TiO(2) nanoparticles inhibited nitric oxide (NO) production from bone marrow-derived macrophages obtained from na?ve mice. When mice were intraperitoneally (IP) injected with < 25 or < 100?nm TiO(2) once a day for 7 days, total cell number of splenocytes was reduced in the spleen of TiO(2) nanoparticle-exposed mice. Both CD4(+) and CD8(+) T-lymphocyte numbers were significantly decreased and B-lymphocyte development was retarded by host exposure to the TiO(2) nanoparticles. LPS-stimulated spleen cell proliferation was significantly reduced by host exposure to < 25 or < 100?nm TiO(2), but no changes were detected in ConA-stimulated spleen cell proliferation. Further, LPS-stimulated cytokine production by peritoneal macrophages and the percentage of NK1.1(+) natural killer cells among splenocytes was reduced by the host exposures to the TiO(2) nanoparticles. When mice were IP injected with TiO(2) nanoparticles once a day for 28 days prior to the subcutaneous implantation of B16F10 melanoma cells, tumor growth was subsequently significantly increased. Collectively, these results show that TiO(2) nanoparticles may damage the development and proliferation of B- and T-lymphocytes, reduce the activity of macrophages, and decrease natural killer (NK) cell population levels, outcomes that appear to lead to an increase in tumor growth in situ. These studies allow us to suggest that TiO(2) nanoparticles might have the potential to enhance tumor growth through immunomodulation of B- and T-lymphocytes, macrophages, and NK cells.

ISSN 

1547-691X

Link 

http://dx.doi.org/10.3109/1547691X.2010.543995

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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