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Title 

Effects of astilbic acid on airway hyperresponsiveness and inflammation in a mouse model of allergic asthma

Authors 

J E YukM Y LeeOk-Kyoung KwonX F CaiHa Yougn JangSei Ryang OhHyeong Kyu LeeKyung Seop Ahn

Publisher 

Elsevier

Issue Date 

2011

Citation 

International Immunopharmacology, vol. 11, no. 2, pp. 266-273

Keywords 

AsthmaAstilbic acidCytokine

Abstract 

Bronchial asthma is characterized by chronic lung inflammation, airway hyperresponsiveness (AHR), and airway remodeling. Astilbic acid, extracted from the medicinal herb Astilbe chinensis, is used as a headache remedy in traditional medicine and has anti-pyretic and analgesic effects. However, the effect of astilbic acid on asthma remains to be established. In the present study, we therefore examined the effect of astilbic acid in a mouse model in which asthma was established by sensitization and challenge with ovalbumin (OVA). Astilbic acid inhibited OVA-induced AHR to inhaled methacholine and significantly suppressed the levels of T-helper 2-type cytokines (including IL [interleukin]-4, IL-5, and IL-13) and inflammatory cells (including eosinophils) in bronchoalveolar lavage (BAL) fluid. Histochemical analysis revealed reduced goblet cell hyperplasia and mucus production, as well as attenuated eosinophil-rich leukocyte infiltration, in the astilbic acid-treated group, compared with OVA-challenged mice. Moreover, the compound significantly inhibited synthesis of IL-4-, IL-5-, IL-13-, IL-17-, and eotaxin-encoding mRNA following asthma induction in lung tissue, in addition to suppressing the immunoglobulin E (IgE) response to asthma in both BAL fluid and serum. Our results indicate that astilbic acid has great potential as a therapeutic candidate for the treatment of asthma.

ISSN 

1567-5769

Link 

http://dx.doi.org/10.1016/j.intimp.2010.12.002

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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